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    PUBLISHED
    

    UNITED STATES COURT OF APPEALS
    

    FOR THE FOURTH CIRCUIT
    

    ------------------------------------------------*

    OPHELIA AZRIEL DE'LONTA, a/k/a M.

    Stokes,

    Plaintiff-Appellant,

    v.

    RONALD J. ANGELONE; M. V. SMITH;

    R. HULBERT, Dr.; COLIN C.J.No. 01-8020
    

    ANGLIKER, Dr.; DOCTOR WRAY,

    Defendants-Appellees,

    and

    DONALD SWETTER, M.D.,

    Defendant.

    ------------------------------------------------*

    Appeal from the United States District Court
    for the Western District of Virginia, at Roanoke.
    James C. Turk, Senior District Judge.
    (CA-99-642-7)
    

    Argued: April 3, 2003
    

    Decided: May 27, 2003
    

    Before WILKINS, Chief Judge, and MOTZ and
    KING, Circuit Judges.
    

    ____________________________________________________________

    Reversed and remanded by published opinion. Chief Judge Wilkins

    wrote the opinion, in which Judge Motz and Judge King joined.

    ____________________________________________________________

    COUNSEL
    

    ARGUED: Kelly Marie Baldrate, VICTOR M. GLASBERG &

    ASSOCIATES, Alexandria, Virginia, for Appellant. Peter Duane

    Vieth, WOOTENHART, P.C., Roanoke, Virginia, for Appellees. ON

    BRIEF: Victor M. Glasberg, VICTOR M. GLASBERG & ASSO-

    CIATES, Alexandria, Virginia; Rebecca K. Glenberg, AMERICAN

    CIVIL LIBERTIES UNION FOUNDATION OF VIRGINIA, Rich-

    mond, Virginia, for Appellant. George W. Wooten, WOOTENHART,

    P.C., Roanoke, Virginia; William W. Muse, Assistant Attorney Gen-

    eral, OFFICE OF THE ATTORNEY GENERAL, Richmond, Vir-

    ginia, for Appellees.

    ____________________________________________________________

    OPINION
    

    WILKINS, Chief Judge:

    Virginia inmate Ophelia Azriel De'lonta (born Michael A. Stokes)

    appeals a district court order dismissing for failure to state a claim,

    see 28 U.S.C.A. § 1915(e)(2)(B)(ii) (West Supp. 2002), her complaint

    under 42 U.S.C.A. § 1983 (West Supp. 2002) claiming prison offi-

    cials have denied her adequate medical treatment in violation of the

    Eighth Amendment. Because we conclude that it does not appear

    beyond doubt that De'lonta cannot prove facts to support her claim,

    we reverse and remand for further proceedings.

    I.1
    

    De'lonta suffers from gender identity disorder (GID) (also known

    as gender dysphoria or transsexualism), a disorder characterized by a

    feeling of being trapped in a body of the wrong gender. She2 has

    undergone various procedures to make herself appear more feminine,

    including dermabrasions and a chemical face peel. She has also

    ____________________________________________________________

    1 Because the district court dismissed De'lonta's complaint for failure

    to state a claim, we accept all of the allegations in her complaint as true,

    construing her pro se complaint liberally. See Estelle v. Gamble, 429

    U.S. 97, 99, 106 (1976); DeWalt v. Carter, 224 F.3d 607, 611-12 (7th

    Cir. 2000) (stating that same standards apply to dismissals under

    § 1915(e)(2)(B)(ii) as apply to dismissals under Fed. R. Civ. P. 12(b)(6)).

    2 We use feminine pronouns to refer to De'lonta, as did the district

    court.

    2
    

    received estrogen treatment to slow hair growth, soften her skin, and

    develop breasts and other female characteristics.

    De'lonta has been in the custody of the Virginia Department of

    Corrections (VDOC) since 1983. Since the beginning of her imprison-

    ment, VDOC doctors have consistently diagnosed her as suffering

    from GID, and De'lonta received estrogen therapy for the disorder in

    1993 while in Greensville Correctional Center. This treatment contin-

    ued until 1995, when De'lonta was transferred to Mecklenburg Cor-

    rectional Center and her hormone treatment was terminated pursuant

    to a then-recently created VDOC policy ("the Policy"). The Policy is

    outlined in a memo dated September 19, 1995, from VDOC Chief

    Physician M. Vernon Smith:

    It is the policy of the Department of Corrections [ ] that nei-

    ther medical nor surgical interventions related to gender or

    sex change will be provided to inmates in the management

    of [GID] cases.

    If an inmate has come into prison and/or is currently receiv-

    ing hormone treatment, he is to be informed of the depart-

    ment['s] policy and the medication should be tapered

    immediately and thence discontinued.

    Inmates presenting with [GID] should be referred to the

    institution[']s mental health staff for further evaluation.

    J.A. 28.

    In contravention of the directive that hormone treatment be tapered

    off, De'lonta's hormone treatment was terminated abruptly, causing

    De'lonta to suffer nausea, uncontrollable itching, and depression.

    The most harmful effect of the cessation of the hormone treatment,

    however, was that De'lonta developed an uncontrollable urge to muti-

    late her genitals. Although she had engaged in some self-mutilation

    previously, it had consisted primarily of cutting her arms and hands.

    Since termination of the hormone treatment, however, she has stabbed

    or cut her genitals on more than 20 occasions. She has repeatedly

    3
    

    requested resumption of the hormone therapy and treatment by a gen-

    der specialist. To date, however, her requests have been denied, and

    her self-mutilation has continued.

    In 1999, De'lonta filed suit against Dr. Smith, other Virginia prison

    doctors, and VDOC Director Ron Angelone (collectively, "Appel-

    lees"), alleging that Appellees have inflicted cruel and unusual pun-

    ishment on her, in violation of her Eighth Amendment rights, by

    denying her adequate medical treatment for her GID. She sought an

    injunction requiring Appellees to arrange for her to be treated by a

    doctor with expertise in transsexualism and to allow her to resume her

    hormone therapy until that treatment commenced. She also requested

    declaratory and monetary relief, including punitive damages.

    Angelone responded by filing a summary judgment motion with an

    attached affidavit. The other Appellees moved to dismiss for failure

    to state a claim. The district court dismissed De'lonta's claims against

    all Appellees pursuant to 28 U.S.C.A. § 1915(e)(2)(B)(ii), concluding

    that the record demonstrated beyond doubt that she could not plead

    facts that would state a valid Eighth Amendment claim. Regarding

    De'lonta's entitlement to adequate treatment for her GID, the court

    ruled that the record was clear that De'lonta was receiving some treat-

    ment. The court concluded that the gravamen of De'lonta's claim was

    simply a disagreement with the medical judgment concerning what

    treatment was appropriate and that such a disagreement did not state

    a claim under the Eighth Amendment. The court also concluded that

    the failure of the VDOC to follow its tapering policy in 1995 did not

    rise to the level of an Eighth Amendment violation. The court further

    ruled that any claim for equitable relief from that conduct had become

    moot, and any legal claim was time-barred.

    In addition, the court denied a motion by De'lonta to amend her

    complaint, concluding that amendment would be futile. Finally,

    although the court stated that it was "unable to conceive of any set of

    facts under which the Eighth Amendment would entitle" De'lonta to

    relief, the court dismissed her complaint without prejudice "[t]o avoid

    complicating any future actions with issues of collateral estoppel or

    claim preclusion."3 J.A. 183, 188.

    ____________________________________________________________

    3 Although a dismissal without prejudice is not normally appealable,

    because the grounds provided by the district court for dismissal "clearly

    4
    

    II.
    

    De'lonta has not challenged the district court ruling that the abrupt-

    ness of the termination of her hormone therapy did not violate the

    Eighth Amendment. She does argue, however, that the district court

    erred in dismissing her remaining claims. The standards for reviewing

    a dismissal under § 1915(e)(2)(B)(ii) are the same as those for

    reviewing a dismissal under Federal Rule of Civil Procedure 12(b)(6).

    See DeWalt v. Carter, 224 F.3d 607, 611-12 (7th Cir. 2000). Thus, we

    review a § 1915(e)(2)(B)(ii) dismissal de novo. See id. "A complaint

    should not be dismissed for failure to state a claim upon which relief

    may be granted unless after accepting all well-pleaded allegations in

    the plaintiff's complaint as true and drawing all reasonable factual

    inferences from those facts in the plaintiff's favor, it appears certain

    that the plaintiff cannot prove any set of facts in support of his claim

    entitling him to relief." Veney v. Wyche, 293 F.3d 726, 730 (4th Cir.

    2002) (internal quotation marks omitted). Additionally, the allega-

    tions in pro se complaints should be liberally construed.4 See Hughes

    v. Rowe, 449 U.S. 5, 9-10 (1980) (per curiam).

    De'lonta's claim arises under the Eighth Amendment. Scrutiny

    under the Eighth Amendment is not limited to those punishments

    authorized by statute and imposed by a criminal judgment. See Wilson

    v. Seiter, 501 U.S. 294, 297 (1991). The Amendment also provides

    protection with respect to "the treatment a prisoner receives in prison

    and the conditions under which he is confined." Helling v. McKinney,

    509 U.S. 25, 31 (1993). Those conditions include the adequacy of the

    medical care that the prison provides. See Estelle v. Gamble, 429 U.S.

    97, 103 (1976).

    ____________________________________________________________

    indicate that no amendment in the complaint could cure the defects in the

    plaintiff's case," we conclude that the order dismissing De'lonta's com-

    plaint is an appealable final order. Domino Sugar Corp. v. Sugar Work-

    ers Local Union 392, 10 F.3d 1064, 1066-67 (4th Cir. 1993) (alteration

    & internal quotation marks omitted).

    4 In dismissing this action, the district court considered all documents

    attached to De'lonta's complaint and to her proposed amended com-

    plaint. Because the parties agree that such consideration was appropriate,

    we have also used the materials to the extent that they clarify the allega-

    tions in the complaint.

    5
    

    The showing necessary to demonstrate that particular conduct by

    prison officials is sufficiently serious to constitute cruel and unusual

    punishment "varies according to the nature of the alleged constitu-

    tional violation." Hudson v. McMillian, 503 U.S. 1, 5 (1992). In order

    to establish that she has been subjected to cruel and unusual punish-

    ment, a prisoner must prove (1) that "the deprivation of [a] basic

    human need was objectively `sufficiently serious,'" and (2) that "sub-

    jectively `the officials act[ed] with a sufficiently culpable state of

    mind.'" Strickler v. Waters, 989 F.2d 1375, 1379 (4th Cir. 1993) (sec-

    ond alteration in original) (quoting Wilson, 501 U.S. at 298). Only

    extreme deprivations are adequate to satisfy the objective component

    of an Eighth Amendment claim regarding conditions of confinement.

    See Hudson, 503 U.S. at 8-9. In order to demonstrate such an extreme

    deprivation, a prisoner must allege "a serious or significant physical

    or emotional injury resulting from the challenged conditions," Strick-

    ler, 989 F.2d at 1381, or demonstrate a substantial risk of such serious

    harm resulting from the prisoner's exposure to the challenged condi-

    tions, see Helling, 509 U.S. at 33-35. The subjective component of an

    Eighth Amendment claim challenging the conditions of confinement

    is satisfied by a showing of deliberate indifference by prison officials.

    See Farmer v. Brennan, 511 U.S. 825, 834 (1994)."[D]eliberate

    indifference entails something more than mere negligence . . . [but]

    is satisfied by something less than acts or omissions for the very pur-

    pose of causing harm or with knowledge that harm will result." Id. at

    835. It requires that a prison official actually know of and disregard

    an objectively serious condition, medical need, or risk of harm. See

    id. at 837; Shakka v. Smith, 71 F.3d 162, 166 (4th Cir. 1995).

    Here, De'lonta contends that her complaint, when liberally con-

    strued, alleges facts sufficient to establish that the denial of treatment

    for her compulsion to mutilate herself constitutes deliberate indiffer-

    ence to her medical needs. In particular, she claims she could prove

    that (1) Appellees know that she suffers from GID; (2) she was

    receiving treatment until 1995, when it was abruptly terminated for

    no legitimate reason; (3) the termination of the therapy has resulted

    in compulsive, repeated self-mutilation of her genitals; and (4) after

    Appellees terminated the hormone treatment, they have refused to

    provide any treatment to prevent her from mutilating herself, leaving

    her at continued risk for serious, self-inflicted injuries. We agree with

    De'lonta that such allegations adequately state a claim for relief and

    6
    

    that the record does not demonstrate beyond doubt that De'lonta

    could not prove those allegations.

    First, De'lonta's need for protection against continued self-

    mutilation constitutes a serious medical need to which prison officials

    may not be deliberately indifferent. See Lee v. Downs, 641 F.2d 1117,

    1121 (4th Cir. 1981) (explaining that "prison officials have a duty to

    protect prisoners from self-destruction or self-injury"). And, nothing

    in the record refutes the allegation that Appellees know that

    De'lonta's compulsive self-mutilation began after the discontinuation

    of her hormone therapy. Nor does the limited record before us demon-

    strate any justification (although there may be one not yet disclosed)

    for either the policy requiring termination of De'lonta's hormone

    treatment or the alleged denial of any other treatment to prevent her

    continuing self-inflicted injuries.

    In dismissing De'lonta's suit, the district court incorrectly deter-

    mined, based on the limited record before it, that the suit was nothing

    more than a challenge to the medical judgment of VDOC doctors.

    This conclusion was based largely on a memorandum to Appellee

    Smith, the VDOC Chief Physician, in which a Dr. Rob Marsh

    reported that De'lonta had requested a referral to a gender specialist

    at the Medical College of Virginia (MCV) for the purpose of discuss-

    ing hormone replacement. The memo states that De'lonta "was

    advised that [Dr. Marsh] did not feel it was a medical necessity or

    indication," but that Dr. Marsh would forward the request to Dr.

    Smith for further review. J.A. 87. Based on this memo, the district

    court concluded that the prison medical staff "did not feel that hor-

    mone therapy or a special consultation were appropriate," id. at 185,

    and therefore that the suit amounted to nothing more than a challenge

    to this medical judgment. For this reason, the court concluded that

    De'lonta's remedy could lie only in a state medical malpractice action

    and not in an Eighth Amendment claim. See Russell v. Sheffer, 528

    F.2d 318, 319 (4th Cir. 1975) (per curiam) (holding that "[q]uestions

    of medical judgment are not subject to judicial review" under § 1983).

    We conclude that the district court was in error. Even assuming

    that Dr. Marsh advised De'lonta as the memo states, nothing in the

    record suggests that Dr. Marsh's opinion was a basis for the denial of

    De'lonta's requested treatment. In fact, Dr. Smith's response to the

    7
    

    memo, which states that there was no gender specialist at MCV and

    that VDOC's policy is not to provide hormone therapy to prisoners,

    supports the inference that Appellees' refusal to provide hormone

    treatment to De'lonta was based solely on the Policy rather than on

    a medical judgment concerning De'lonta's specific circumstances. Cf.

    Supre v. Ricketts, 792 F.2d 958, 963 (10th Cir. 1986) (holding that

    prisoner who had engaged in self-mutilation was not entitled to hor-

    mone treatment for gender dysphoria because denial of such treatment

    was based on "an informed [medical] judgment").

    Moreover, Dr. Marsh's memo is at most only a comment on the

    appropriateness of one possible treatment and does not refute

    De'lonta's claim that she has not received any treatment to suppress

    her compulsion to mutilate herself. Cf. id. ("This case . . . does not

    present a situation where there was a total failure to give medical

    attention."); id. at 967 (Seymour, J., dissenting) (concluding that

    deliberate indifference claim "was plainly not unfounded" when "re-

    cord contain[ed] no proof that prison physicians ever addressed

    whether [prisoner's] self-mutilation might have been . . . in need of

    treatment"). But cf. Maggert v. Hanks, 131 F.3d 670, 672 (7th Cir.

    1997) (holding that prisoner was not constitutionally entitled to cura-

    tive treatment for gender dysphoria, but not indicating that prisoner

    was at risk for self-mutilation or other serious bodily harm). At oral

    argument, Appellees argued that even if Dr. Marsh's memo does not

    show that De'lonta received treatment for her GID, De'lonta's other

    submissions demonstrate that she has been housed at a facility for

    inmates who need special attention to mental health issues and that

    De'lonta has received counseling and anti-depressants. Appellees

    pointed specifically to a mental health evaluation stating that De'lonta

    had "been receiving Prozac and . . . Doxepin which appear to assist

    h[er] in h[er] mood symptoms" and that "[De'lonta states] that the

    Prozac helps h[er] with h[er] urges to cut on h[er]self." J.A. 90. These

    submissions, however, only indicate that some treatment De'lonta

    received may have alleviated her compulsion to mutilate herself; they

    do not clearly demonstrate that the treatment was provided for that

    purpose or that it was deemed to be a reasonable method of prevent-

    ing further mutilation.

    For all of these reasons, we conclude that it does not appear beyond

    doubt at this early stage of the litigation that De'lonta cannot prove

    8
    

    facts sufficient to support her claim that she has not received constitu-

    tionally adequate treatment to protect her from her compulsion to

    mutilate herself. We therefore reverse the district court order dismiss-

    ing De'lonta's suit and remand to the district court for further pro-

    ceedings. In so doing, we make no comment on the merits of any

    issues not yet addressed by the district court, and we specifically

    make no comment on the type of treatment, if any, to which De'lonta

    is entitled.

    III.
    

    In sum, we reverse the dismissal of De'lonta's § 1983 suit and

    remand to the district court for further proceedings consistent with

    this opinion.5

    REVERSED AND REMANDED
    

    ____________________________________________________________

    5 Appellees argue that Angelone should be dismissed from this suit

    even if De'lonta has stated a valid Eighth Amendment claim against

    other Appellees. Because the district court has yet to rule on this issue,

    we decline to do so in this appeal.

    De'lonta's motions to supplement the record are denied.

    9
    

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